郭欠欠，博士，副教授，硕士/博士研究生青年导师，贵州医科大学药学院制剂工程学教研室主任。

个人简介：2011年获得厦门大学材料学院学士学位，2017年获得南开大学化学学院博士学位。2017年-至今，任职于贵州医科大学药学院，从事教学科研工作。近年来，主持国家自然科学基金3项，省部级项目3项，贵州医科大学优秀青年人才、贵州省千层次人才。发表SCI论文27篇。

联系方式：guoqq_2020@126.com

1.研究方向

（1）智能高分子材料研究

（2）抗菌高分子材料研究

（3）高分子药物递送系统的设计与应用

2.主持的科研项目

（1）贵州省教育厅自然科学研究项目，青年科技拔尖人才项目，具有增强细菌粘附和自愈活性的光热抗菌水凝胶用于治疗耐药菌伤口感染的研究，贵州省教育厅，2025.01至2027.12，40万元，在研

（2）国家自然科学基金，地区科学基金项目，52263014，肾脏特异性蓄积的ROS响应性脂质纳米药物治疗急性肾损伤的研究，2023.01至2026.12，33万元，已结题

（3）国家自然科学基金，地区科学基金项目，52063009，具有阻断细菌群体感应系统作用的生物响应性抗菌材料研究，2021.01至2024.12，35万元，已结题

（4）贵州医科大学，优秀青年人才，贵医大优秀青年人才2020（103），具有特异性捕捉细菌作用的杂多价光热纳米材料用于治疗细菌感染的研究，2020.06至2025.06，100万元，在研

（5）贵州省科技厅，科学技术基金，黔科合基础[2020]1Y210，艳山姜挥发油挥发油纳米材料用于防治糖尿病视网膜病变的研究，2020-03至2023-03，10万元，已结题

（6）国家自然科学基金，青年科学基金项目，51903063，基于细菌感染微环境构建逆转细菌耐药性抗菌材料的研究，2020-01至2022-12，22万元，已结题

3.近五年代表性论文

(1)Qianqian Guo^#, Xin Lu^#, Yanqi Zhang, Zhimin Huang, Shaobo Liu, Li Qiao, Xingjie Wu, Honglei Guo,^*Xiangchun Shen,^*and Huijuan Mao^*. A Nanoplatform Targeting Cascade Pathways for Enhanced Triptolide Delivery in Acute Kidney Injury Therapy. Advanced Healthcare Materials, 2025. DOI: 10.1002/adhm.202500595.

(2)Tianyu Lan, Mei Li, Xiuheng Luo, Haijun Du, Xin Lu, Huijuan Mao,* Honglei Guo,* andQianqian Guo*. Enhanced Renal Protection in Acute Kidney Injury with ROS-Activated Nanoparticles Targeting Oxidative Stress and Inflammation. ACS Biomaterials Science & Engineering, 2025, 11, 5, 2713–2726.

(3)Qianqian Guo^#,*, Kedui Geng^#, Jiangmin Wan, Tianyu Lan, Xin Lu, Ling Tao, Kunyuan Duan,, Wen Zhou,, Honglei Guo*, Xiangchun Shen*. Lysozyme-targeted liposomes for enhanced tubular targeting in the treatment of acute kidney injury. Acta Biomaterialia, 2025,192, 394–408

(4)Yongjun Luo, Zhenglan Gao, Honglei Guo, Kunyuan Duan, Tianyu Lan*, Buhui Tao, Xiangchun Shen*,Qianqian Guo*. Multifunctional Photothermal Nanorods for Targeted Treatment of Drug-Resistant Bacteria-Induced Wound Healing.ACS Applied Materials & Interfaces, 2024, 16, 38, 51480–51495

(5)Jijin Li,^#Tianyu Lan,^#Qianqian Guo*, Chuang Zhang, Xin Lu, Xiaoxia Hu, Xiangchun Shen,* Yanyan Zhang*.Mitochondria-Targeted Natural Antioxidant Nanosystem forDiabetic Vascular CalcificationTherapy.Biomacromolecules, 2024, 25, 4329−4343.

(6)Honglei Guo^#,Tianyu Lan^#,*,Xin Lu, Kedui Geng, Xiangchun Shen, Huijuan Mao*,andQianqian Guo^*. ROS-responsivecurcumin-encapsulatednanoparticles for AKItherapy viapromotinglipiddegradation in therenaltubule.Journal of Materials Chemistry B, 2024, 12, 3063.

(7)Yongjun Luo, Xiaoping Zhu, Jun Qian, Yiyi Yu, Jing Li, Zhiyong He, Suyan Duan, Honglei Guo,* Xiangchun Shen,* andQianqian Guo*.Aunanorods coated with pH-responsive polymers for photothermal therapy against multidrug-resistant bacteria. ACS Applied Nano Materials, 2022, 5, 16884−16895

(8)Tianyu Lan,^#Honglei Guo,^#Xin Lu, Kedui Geng, Lin Wu, Yongjun Luo, Jingfeng Zhu, Xiangchun Shen,*Qianqian Guo,*and Shuizhu Wu*; Dual-responsivecurcumin-loadednanoparticles for thetreatment ofcisplatin-inducedacutekidneyinjury. Biomacromolecules, 2022, 23, 12, 5253–5266.

(9)Qianqian Guo*, Yongjun Luo, Honglei Guo, Tianyu Lan, Shengquan Wang,Kedui Geng, Xin Lu, Ling Tao, Xiangchun Shen*; A photo-thermal nanocomposite capable of relieving inflammatory response to compete multidrug-resistant pseudomonas aeruginosa infection,Chemical Engineering Journal，2022, 446: 137173.

(10)Qianqian Guo*, Honglei Guo, Tianyu Lan, Yi Chen, Xueyun Chen, Ya Feng, Yongjun Luo, Yifang Yao, Yafei Li, Xiuhao Pan, Yini Xu, Ling Tao, Yujia Liu, Xiangchun Shen*; Co-delivery of antibiotic and baicalein by using different polymeric nanoparticle cargos with enhanced synergistic antibacterial activity,International Journal of Pharmaceutics，2021, 599: 120419.