傅晓钟，博士，教授，硕士研究生导师，贵州医科大学骨干教师，药学院药物化学教研室主任，药物化学学科联系人，药学院党委委员，贵州省第九批优秀青年科技人才培养对象，贵州省优秀教师，中组部第十批“西部之光”访问学者，国家职业资格鉴定高级考评员，国家自然科学基金通讯函评专家，科学出版社药学本科《药物化学》“十三五”规划教材副主编。国际著名学术期刊Journal of Medicinal Chemistry, Medicinal Chemistry Research, Journal of Pharmacy and Pharmacology , Current Medicinal Chemistry杂志审稿人。

一、主持的代表性研究项目

1、基于脑靶向性转运机制的灯盏乙素苷元衍生物设计与合成， 国家自然科学基金（No. 81260473）

2、基于肝靶向性转运机制的阿德福韦单L-氨基酸酯，单胆酸酯衍生物的设计、合成与生物活性研究，国家自然科学基金（No. 81460523）

3、基于肾毒性降低与抗乙肝病毒活性增强的阿德福韦前药设计与合成， 国家自然科学基金（No. 20962004）

4、灯盏乙素及其苷元L-氨基酸氨基甲酸酯类衍生物的设计、合成及抗氧化作用机制研究，贵州省优秀青年科技人才培养对象专项资金（黔科合人字2013-45号）

5、基于肝靶向性转运机制的阿德福韦胆酸衍生物的设计与合成， 贵州省社会发展攻关计划项目（No. 2013-3031号）

6、基于脑靶向性转运机制的灯盏乙素苷元衍生物设计与合成， 贵州省中药现代化科技产业研究开发专项（黔科合ZY字2012-3013号）

7、贵州省“一流课程”药物化学（培育）建设，贵州省教育厅2017年立项，2020年通过验收。

二、发表代表性研究论文、专利、获得学术奖励以及教材参编情况

（一）期刊论文

1. Dirong Wu, Jiao Chen, Keke Luo, Hui Li, Ting Liu, Li Li, Zeqin Dai, Yongjun Li, Yonglong Zhao,Xiaozhong Fu*Design, synthesis and evaluation of novel scutellarin and scutellarein-N, N-bis-substituted carbamate-L-amino acid derivatives as potential multifunctional therapeutics for Alzheimer’s disease.Bioorg Chem2022,122,105760

2. Tao Lia, Dirong Wu, Yang Yang, Tao Xiao, Yilin Han,Jing Li, Ting Liu,Li Li, Zeqin Dai, Yongjun Li,Xiaozhong Fu*Synthesis, pharmacological evaluation and mechanistic study of scutellarin methyl ester -4′-dipeptide conjugates for the treatment of hypoxic-ischemic encephalopathy (HIE) in rat pups.Bioorg Chem2020, 101, 103980

3. Tao Li, Jing Li, Yang Yang, Yilin Han, Dirong Wu, Tao Xiao,Yang Wang, Ting Liu, Yonglong Zhao, Yongjun Li, Zeqin Dai,Xiaozhong Fu*Synthesis, pharmacological evaluation, and mechanistic study of adefovir mixed phosphonate derivatives bearing cholic acid and L-amino acid moieties for the treatment of HBV.Bioorg Med Chem2019,27,3707–3721

   4. Yongxi Dong, Li Dong,Jinglei Chen, Min Luo,Xiaozhong Fu*, Chunhua Qiao Synthesis and biological evaluation of N-alkyl-1,4-dihydroquinoline prodrugs of scutellarin methyl ester as neuroprotective agents.Med Chem Res.2018, 27, 1111-1121.

   5. Ya Chen, Wen Zheng Zhang, Jing Li, Tao Xiao, Jiang Xia Liu, Min Luo, Hang Su,Xiao-Zhong Fu*, Ting Liu, Yong-Xi Dong, Yong-Long Zhao, Bin He, Yong-Jun Li. Novel adefovir mono L-amino acid ester, mono bile acid ester derivatives: Design, synthesis, biological evaluation, and molecular docking study.Med Chem Res.2017, 26, 1812-1821.

   6.Yu Ou, Min Luo, Yong-Xi Dong, Hang Su,Xiao-Zhong Fu*, Yu-Feng Cha,Shun Zhang, Yong-Long Zhao, Yong-Jun Li, Yong-Lin Wang.Permeability of novel 4′-N-substituted (aminomethyl) benzoate-7- substituted nicotinic acid ester derivatives of scutellarein in Caco-2 cells and in an invitro model of the blood-brain barrier.Med Chem Res.2016, 25,2205-2213.

   7.Yu-Feng Cha, Shun Zhang, Hang Su, Yu Ou,Xiao-Zhong Fu*, Feng-Jie Jiang,Yong-Long Zhao, Yong-Xi Dong, Min Luo, Yong Huang,Yan-Yu Lan, Ai-Min Wang, Yong-Lin Wang. L-Aminoacid carbamate prodrugs of scutellarin: synthesis, physiochemical property,Caco-2 cell permeability, and In Vivo anti-oxidative activityMed Chem Res.2015, 24, 2238-2246.

   8. Ze-Qin Dai, Hang Su, Min Luo, Yu Ou,Xiao-Zhong Fu*,Yu-Feng Cha, Shun Zhang, Yong Huang, Yong-Lin Wang. Applicationof N-substituted (aminomethyl) benzoate Strategy in Design of ScutellareinDerivatives with Improved Caco-2 Cell Permeability and In vitro AntioxidativeActivityBull K Chem Soc2015, 36,1959-1965.

   9.Xiaozhong Fu*, FengjieJiang, Yu Ou, Sheng Fu, Yufeng Cha, Shun Zhang, Zongyuan Liu, Wen Zhou,Yonglin Wang* Synthesis and anti-HBV evaluation of mono L-amino acidester, mono non-steroid anti-inflammation drug carboxylic ester derivatives ofacyclonucleoside phosphonates.Chin Chem Lett2014，25，115-118

   10.FengjieJiang,Xiaozhong Fu*, Shanwu Wang, Yong Huang, Wen Zhou, Aimin Wang and Yonglin Wang*.Synthesis and physiochemical property evaluationof carbamate derivatives of scutellarin methyl esterChin Chem Lett2013, 24, 338-340

   11.Xiao-Zhong Fu, Yu Ou,Jian-Ying Pei,Ying Liu, Jing Li, Wen Zhou, Yan-Yu Lan, Ai-Min Wang and Yong-Lin Wang *. Synthesis, anti-HBV activityand renal cell toxicity evaluation of mixed phosphonate prodrugs ofadefovirEur J Med Chem2012, 49,211-218.

   12.Xiao Zhong Fu, Yu Ou, Jian Xin, Yu She Yang*. Design,synthesis and in vivo evaluation of mono (2,2,2- tri- fluoroethyl) esters, monoL-amino acid ester prodrugs of acyclic nucleoside phosphonates as anti-HBVagents.Chin Chem Lett2011, 22,1387-1390.

   13.Xiao-ZhongFu, Feng-Jing Xing, Yan-Yu Lan, Ai-Min Wang, Yong-Lin Wang,* Jing Li, Wen Zhou, Wei Zhang, Ying Liu. Synthesis and in vitroanti-oxidative activity studies of 4’-N-substituted (amino methyl) benzoatederivativesof Scutellarein.Chin J Org Chem,2011,31(7) : 1043-1048.

   14.Xiao-Zhong Fu*, Ying Huang, Zhu Tao, Sai-Feng Xue, Chun Luo, Yu Ou, Jian-XinZhang. Investigation of Complex of Cucurbit[6, 7, 8]urils with AdefovirBis(L-amino acid) Ester Prodrug and Its Anti-HBV Activity.Chin J Org Chem2010, 30 (5):675-683.

   15.Xiaozhong Fu, SaihongJiang, Peng Lu, Yushe Yang*, Ruyun Ji. An improved synthetic process for YF-6,A promising anti-HBV drug candidate.Org Prep Proced In2008, 40 (5): 467-470.

   16.Xiaozhong Fu, SaihongJiang, Chuan Li, Jian Xin, Yushe Yang*, Ruyun Ji. Design and synthesis of novelbis(L-amino acid) ester prodrugs of 9-[2- (phosphono methoxy) ethyl] adenine(PMEA) with improved anti-HBV activity.Bioorg. Med Chem Lett2007, 17(2): 465-470.

   17.Xiaozhong Fu, Sai Hong Jiang, Jian Xin, Yushe Yang*. Design,synthesis and in vitro Evaluation of L-amino acid esters prodrugs of acyclicnucleoside phosphonates as anti-HBV agent.Chin Chem Lett2007,18(7): 817-819.

   （二）获得授权发明专利情况

   1.傅晓钟;王永林;苏航;兰燕宇;李勇军;王爱民;黄勇;陈雅;罗敏;张文政 阿德福韦单硫代L-氨基酸酯单胆酸酯衍生物及其制备方法 获得授权发明专利 专利授权号：ZL 201610427712.0。授权时间2020.5.22

   2.杨玉社，傅晓钟，李战，嵇汝运嘌呤类化合物双氨基酸酯的制备方法与用途。授权时间2011.2.16，中国，专利授权号：ZL200610024401.6。

   3.杨玉社，傅晓钟，李战，嵇汝运用于治疗乙型肝炎的嘌呤类化合物及其制备方法和用途。授权时间2011.9.21，中国，专利授权号：ZL200610027328.8。

   （三）获得奖励情况

   1、傅晓钟，黄英，陶朱，薛赛凤，罗春，欧瑜，张建新.“Investigation of Complex of Cucurbit [6, 7, 8]urils with Adefovir Bis(L-amino acid)Ester Prodrug and Its Anti-HBV Activity，Chinese Journal ofOrganic Chemistry 2010, 5, 675-683 ”论文获得贵州省首届优秀医学学术论文三等奖，获奖时间2011年2月，授奖部门贵州省卫生厅、贵州省科教办。

   2、傅晓钟贵州省第九批优秀青年科技人才培养对象，获奖时间2013年4月，授奖部门贵州省优秀青年科技人才培养领导小组。

   3、傅晓钟贵州省优秀教师，获奖时间2013年9月，授奖部门贵州省教育厅，贵州省人力资源与社会保障厅。

4. 教材参编情况

5. 傅晓钟参编由中国医药科技出版社出版的全国高等医药院校药学类专业第五轮规划教材《药物化学》（第三版）,出版时间2020.1。

6. 傅晓钟副主编参编由科学出版社出版的《药物化学》普通高等教育“十三五”规划教材，全国高等医药院校药学类系列规划教材，出版时间2018.1。

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