博士研究生导师，三级教授，研究方向：抗肿瘤药物药理学；中药抗肿瘤药物药理学。

2012年6月于中国药科大学获得药理学博士学位，2013年12月晋升为副教授，2016年12月晋升为教授。荣获贵州省首批人才团队托举项目、贵州省优秀青年科技人才、贵州省教育厅优秀科技青年人才、贵州省“千层次”人才、贵州省科技拔尖人材以及贵州省高等学校“金师”荣誉称号。共主持国家自然科学基金项目4项以及省部级科研项目11项，以第一作者或通讯作者在Blood、Cancer Letters、Oncogene、Journal of Experimental & Clinical Cancer Research等期刊发表论文40余篇，其中SCI论文27篇，中科院1区TOP期刊16篇，封面文章1篇。获得贵州省青年科技奖、贵州省医学会科技奖一等奖1项（第一完成人），全国药学青年教师微课大赛特等奖，全国药学青年教师教学技能大赛二等奖，省级教育科学研究优秀成果奖4项，以及贵州省高等学校科学研究优秀成果奖1项。目前任贵州省药理学会副理事长、贵州省药学会科普专业委员会副主任以及贵州省药学院青年委员会副主任等职务。

近5年发表论文

（1）Shuangqin Fan, Xiaomin Yan, Xiaoxia Hu, Xing Liu, Shijie Zhao, Yue Zhang, Xiaofeng Zhou, Xiangchun Shen*, Qi Qi* andYan Chen*. Shikonin blocks CAF-induced TNBC metastasis by suppressing mitochondrial biogenesis through GSK-3β/NEDD4-1 mediatedphosphorylation-dependent degradationof PGC-1α.Journal of Experimental & Clinical Cancer Research, 2024, 43:180.

（2）Yi Chen, Shan Xu, Shuang Ren, Jiyuan Zhang, Jinzhuan Xu, Yuxuan Song, Jianqing Peng, Shuai Zhang*, Qianming Du*,Yan Chen*. Design of a targeted dual drug delivery system for boosting the efficacy of photoimmunotherapy against melanoma proliferation and metastasis.Journal of Advanced Research.2024,J Adv Res. 2025,71:533-550.

（3）Yuxuan Song, Shuang Ren, Xingmei Chen, Xuhong Li, Lin Chen, Shijie Zhao, Yue Zhang*, Xiangchun Shen*,Yan Chen*. Inhibition of MFN1 restores tamoxifen-induced apoptosis in resistant cells by disrupting aberrant mitochondrial fusion dynamics.Cancer Letters, 2024, 590: 216847.

（4）Jianqing Peng, Jia Zhou, Xing Liu, Xiaobo Zhang, Xiang Zhou, Zipeng Gong, Yi Chen*, Xiangchun Shen*,Yan Chen*. A biomimetic nanocarrier facilitates glucose consumption and reactive oxide species accumulation in enzyme therapy for colorectal cancer.Journal of Controlled Release. 2024,367:76-92.

（5）Jia Zhou, Zhaohui Jiang, Runbin Sun, Di Pan, Qianming Du, Xiang Zhou,Yi Chen*,Yan Chen*, Jianqing Peng*.Comparison of cell delivery and cell membrane camouflaged PLGA nanoparticles in the delivery of shikonin for colorectal cancer treatment.Colloids Surf B Biointerfaces.2024, 241:114017

（6）Xiaoxia Hu, Xiaoyu Peng, Yue Zhang, Shuangqin Fan, Xing Liu, Yuxuan Song, Shuang Ren, Lin Chen, Yi Chen, Rong Wang, Jianqing Peng*, Xiangchun Shen*,Yan Chen*. Shikonin reverses cancer-associated fibroblast-induced gemcitabine resistance in pancreatic cancer cells by suppressing monocarboxylate transporter 4-mediated reverse Warburg effect.Phytomedicine,2024,123:155214.

（7）Yue Zhang, Yuxuan Song, Shuang Ren, Minqin Zhang, Zhao Zhang, Shuangqin Fan, Xing Liu, Xiaoyu Peng, Qi Qi*, Xiangchun Shen*,Yan Chen*. GPER-mediated stabilization of HIF-1α contributes to upregulated aerobic glycolysis in tamoxifen-resistant cells.Oncogene, 2023, 42(3):184-197.

（8）Jianqing Peng, Xiaoxia Hu, Shuangqin Fan, Jia Zhou, Shuang Ren, Runbin Sun, Yi Chen*,Xiangchun Shen*, andYan Chen*. Inhibition of Mitochondrial Biosynthesis using a“Right-Side-Out” Membrane-Camouflaged Micelle toFacilitate the Therapeutic Effects of Shikonin onTriple-Negative Breast Cancer.Adv Healthc Mater. 2022, 12;e2200742.

（9）Yan Chen, Jingyu Zhang, Minqin Zhang, Yuxuan Song,Yue Zhang, Shuangqin Fan, Shuang Ren, Lingyun Fu, Nenling Zhang, Hui Hui, Xiangchun Shen. Baicalein resensitizes tamoxifen-resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia inducible factor-1α.Clinical and Translational Medicine. 2021,11(11): e577.

（10）Lin Chen, Xuhong Li, Shijie Zhao, Mengyu Hao, Heng Wang, Zhi Zhou, Xinyu Xiong, Die Yuan, Piao Lu, Luwen Wang, Di Pan, Xiangchun Shen*, Yue Zhang*,Yan Chen*.Puerarin Inhibits Proliferation, Migration and Invasion of Colon Cancer Cells and Induces Apoptosis via Suppression of the PI3K/AKT Signaling Pathway.Pharmaceuticals (Basel).2025,18(9):1378.

（11）Lin Chen, Shijie Zhao, Qianyu Chen, Piao Luo, Xuhong Li, Yuxuan Song, Shenghai Pan, Qingmei Wu, Yue Zhang, Xiangchun Shen*,Yan Chen*.Poria cocos polysaccharides ameliorate AOM/DSS-induced colorectal cancer in mice by remodeling intestinal microbiota composition and enhancing intestinal barrier function.Int J Biol Macromol. 2025,315(Pt 2):144477.

（12）Yongxin Chen, Hong Yang, Dasong Wang, Tingting Chen, Xiaolan Qi, Ling Tao*,Yan Chen*, Xiangchun Shen*. Gastrodin alleviates mitochondrial dysfunction by regulating SIRT3-mediated TFAM acetylation in vascular dementia. Phytomedicine. 2024, 128:155369.

（13）YongXin Chen, Hong Yang, DaSong Wang, Yuting Yao, Tingting Chen, Ling Tao,Yan Chen*, Xiang-Chun Shen*. Gastrodin relieves cognitive impairment by regulating autophagy via PI3K/AKT signaling pathway in vascular dementia.Biochem Biophys Res Commun. 2023,671:246-254.

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