赵永龙，教授，博士生（学术）导师。汉族，1986年8月生，贵州遵义人，中国共产党员。2009年毕业于兰州大学化学(国家基地班）本科专业, 2014年6月在兰州大学功能有机分子化学国家重点实验室有机化学专业获理学博士学位。于2014年7月到贵州医科大学（原贵阳医学院）药物化学教研室工作，现任药物化学教研室副主任，兼任中国民族医药学会方药量效研究分会常务理事、中国医药教育协会中医药慢病防治与教育工作委员会常务委员、贵州省药学会药物化学分会委员,教育部学位与研究生教育发展中心学位论文评议专家,Organic Letters和Organic Chemistry Frontiers等国际期刊杂志审稿人等。先后入选贵州医科大学青年骨干教师，中组部第十七批“西部之光”访问学者，贵州医科大学“优秀教师”和“师德先进个人”，贵州医科大学优秀本科和硕士论文指导教师等称号；指导学生获校级本科和硕士优秀毕业论文、研究生国家奖学金、第三届西部地区药学研究生创新学术论坛二等奖、第二届全国药学研究生学术研讨会口头报告优秀奖和贵州省普通高等学校优秀毕业生等多项奖励。课题组长期从事不对称催化、药用活性天然产物深度开发和靶向药物方面的研究工作。迄今为止主持国家自然科学基金项目2项，其它省部级和市厅级项目近10项。以第一或通讯作者在Journal of Medicinal Chemistry、Green Chemistry、Organic Letters、Organic Chemistry Frontiers等国际著名刊物上发表研究论文20余篇,申请发明专利4项，授权3项。
主持代表性项目：
（1）国家自然科学基金青年项目，21502030，2016/01-2018/12，主持
（2）国家自然科学基金地区项目，22061011，2021/01-2024/12，主持
（3）省部共建药用植物功效与利用国家重点实验室开放课题, FAMP201904K，2019/12-2021/11，主持
（4）贵州省卫生健康委基金项目，gzwjkj2020-1-209，2021/01-2022/12，主持
（5）贵州省科技厅项目，黔科合基础[2020]1Y03，2020/03-2023/03，主持
代表性研究论文：
1.C. Lin,‡ J.-H. He,‡ M.-L. Rao, G.-P. Yang, W.-J. Li, M. Zhou, C. Zhao, X.-Z. Fu, B. He,Y.-L. Zhao*. Chiral Phosphoric Acid Catalyzed Asymmetric Mannich Reaction of 2-Aryl-3H-indol-3-ones with α-H Diazoacetates.Org. Lett.,2025,7, 3048.
2.M.Zhang,†X.-H.Fei,†G.-P.Yang,†C.Lin, W.-J.Li, M.-L.Rao, M.Zhou, C.Zhao,*B.He,* andY.-L.Zhao*. Chiral Synthetic Unprecedented Spiro[indoline-2,3'-thiophen]-3-ones via Organocatalytic Asymmetric Sulfa-Michael/Aldol Cascade Reaction.Org. Chem. Front.,2024,11,6426.
3.X. Guan,† W.-J. Li,† M.-S. Shuai,† M. Zhang, C.-C. Zhou, X.-Z. Fu, Y.-Y. Yang, M. Zhou, B. He, andY.-L. Zhao*. Rh(III)-Catalyzed C7-Alkylation of Isatogens with Malonic Acid Diazoesters.J. Org. Chem.2024,89, 2984.
4.Q.-Q. Zhang,† F. Jin,† J.-h. Yu, C. Zhang, M. Zhang, M.-Z. Deng, S.-X. Lin, L. Chen,Y.-L. Zhao,*Bin He,* and Yan Li*. Preparation of Indolin-3-one-Containing 1,4-Naphthoquinone Derivatives via Organocatalytic Asymmetric Michael Addition Reaction.J. Org. Chem.2024,89, 10099.
5.M. Zhang,‡ F.-F. Yang,‡ X. Guan, M.-S. Shuai, Q.-Q. Zhang, X.-Z. Fu, Y.-Y. Yang, M. Zhou, B. He, andY.-L. Zhao*. Construction of C2-spirocyclopropyl-indolin-3-ones via Basepromoted [2+1] Annulation Reaction of Indolin-3-ones with Bromosulfonium Salts.Eur. J. Org. Chem.2023,26, 7.
6.M.-S. Shuai,‡ X. Guan,‡ X.-H. Fei, M. Zhang, X.-Z. Fu, B. He, andY.-L. Zhao*.Synthesis of diarylmethyl thioethers via DABCO catalyzed 1,6-conjugate addition reaction ofp-Quinone Methides with Organosulfur Reagents.RSC Adv.,2023,13, 12982.
7.Y.-L. Zhao, X.-W. Long, H. Wu, J. Deng*. Recent Advances of Cytochalasans Natural Products Total Synthesis Using Bioinspired Strategies.Org. Chem. Front.,2022,9, 6979.
8.F.-F. Yang,‡ M.-S. Shuai,‡ X. Guan, M. Zhang, Q.-Q. Zhang, X.-Z. Fu, Z.-Q. Li, D.-P. Wang, M. Zhou, Y.-Y. Yang, T. L., B. He and andY.-L. Zhao*. Synthesis and antibacterial activity studies in vitro of indirubin-3' -monoximes.RSC Adv.,2022,12, 25068.
9.Zhao Y.-L.,+,*An J.-X.,+ Yang F.-F., Guan X., Fu X.-Z., Li Z.-Q., Wang D.-P., Zhou M., Yang Y.-Y., and He B.,* One-pot Asymmetric Oxidative Dearomatization of 2-Substituted Indoles by Merging Transition Metal Catalysis with Organocatalysis to Access C2-tetrasubstituted Indolin-3-ones.Adv. Synth. Catal.2022,364,1277.
10.Cao Z.-X.,§ Yang F.-F.,§ Wang J., Gu Z.-C., Lin S.-X., Wang P., An J.-X., Liu T., Li Y., Li Y.-J., Lin H.-N.,Zhao Y.-L.,*and He B.*. Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer.J. Med. Chem.2021,64, 15280.
11.Fei X.-H.,#Zhao, Y.-L. *,#, Yang F.-F., Guan X., Li Z.-Q., Wang D.-P., Zhou M., Yang Y.-Y., and He B.. Construction of Oxepino[3,2-b] indoles via [4+3] Annulation of 2-Ylideneoxindoles with Crotonate-Derived Sulfur Ylides.Adv. Synth. Catal.2021,363, 3018.
12.Zhao, Y.-L.*,#,Tang,Y.-Q.#,Fei, X. H.,Yang, F.-F.,Cao, Z.-X.,Duan, D. Z.,Zhao, Q.-J.,Yang, Y.-Y.,Zhou, M.,Bin He*. Direct C(sp3)–H acyloxylation of indolin-3-ones with carboxylic acids catalysed by KI.Green Chem.,2020,22, 2354.
13.Zhao, Y.-L.*,#; Fei, X.-H.#; Tang, Y.-Q.; Xu, P.-F.; Yang, F.-F.; An, J.-X.; He, B.; Fu, X.-Z.; Yang, Y.-Y.; Zhou, M.; Mao, Y.-H.; Dong, Y.-X.; Li, C. Organocatalytic Asymmetric α-Sulfenylation of 2-Substituted Indolin-3-ones: A Strategy for the Synthesis of Chiral 2,2-Disubstituted Indole-3-ones with S- and N-Containing Heteroquaternary Carbon Stereocenter.J. Org. Chem.,2019,84, 8168.
14.Zhao, Y.-L.,Wang, Y,Luo, Y.-C.,Fu, X.-Z.,Xu, P.-F.*. Asymmetric C–H functionalization involvingorganocatalysis.Tetrahedron Lett.,2015,56, 3703.
15.Zhao, Y.-L.,Wang, Y,Jian, Cao,Liang, Y.-M.* and Xu, P.-F.*. Organocatalytic Asymmetric Michael–Michael Cascade for the Construction of Highly Functionalized N-FusedPiperidinoindoline Derivatives.Org. Lett.,2014,16, 2438.
16.Zhao, Y.-L.,Wang, Y,Hu, X.-Q.,Xu, P.-F.*. Merging organocatalysis with transitionmetal catalysis and using O2as the oxidant for enantioselective C-H functionalization of aldehydes.Chem. Commun.,2013,49, 7555.
专利情况：
(1)何彬,赵永龙,曹灼贤,杨芬芬,李燕,李勇军.一种靛玉红衍生物及其作为CDK/HDAC双靶标抑制剂的应用.中国专利, 2020.11.26, ZL201910575031.2 (授权号：CN 110590640 B）
(2)赵永龙,唐永琴,费兴海,杨芬芬,安建雄. N-乙酰基-3-氧吲哚类化合物及其C2位的C-O键的构建方法.中国专利, 2021.09.28,ZL201911295627.3 (授权号：CN110922350 B)
(3)赵永龙，杨芬芬，何彬，帅明杉，管香，张茂，林成.靛玉红-3′-肟类化合物在制备抗菌剂中的应用.中国专利, 2024.01.12,ZL.202210483575.8 (授权号：CN114712348B)
(4)赵永龙，张茂，费兴海，林成，周潮超，帅明杉，李文杰，饶明亮.手性螺[二氢吲哚-2,3'-噻吩]-3-酮衍生物及其制备方法和应用.中国专利, 2024.09.16,ZL.202410119774.X(授权号：CN111187270B).
