(1)主持贵州省科技重大专项《抗肿瘤(白血病、乳腺癌等)药物新靶标模型的组建及其在新药研发上的应用》(编号:黔科合重大专项字[2013]6012),2013.08-2016.12,贵州省科技厅,200万元。
(2)作为中方负责人共同主持国家自然科学基金面上项目《大鼠和人乳腺癌易感基因RGD1560402的鉴定及功能特征研究》(编号:81472609),2015.01- 2018.12,国家自然科学基金委,75万元。
(3)主持国家基金青年科学基金《Fli-1激动剂抑制前列腺癌细胞生长、转移与侵袭的分子机制》(编号:81702914),2018.01-2020.12,25万元。
(4)主持贵州省科学技术基金重点项目《RecQ家族DNA解旋酶在前列腺癌细胞转移中的功能机制研究》(编号:黔科合基础[2017]1412),2017.12-2020.12,30万元。
(5)主持中国博士后科学基金特别资助项目《Fli-1基因在前列腺癌发生中的功能机制研究》(编号:2015T80106),2015.07-2017.07,中国博士后管理委员会,15万元。
(6)主持北京市博士后科学基金《Fli-1调控前列腺癌细胞生长的分子机制研究》(编号:2015-ZZ-45),2015.07-2017.07,北京市博士后管理委员会,5.2万元。
(10)主持贵州省科技支撑计划《Fli-1基因靶向抑制剂在治疗Friend病毒诱导的红白血病中的应用研究》(编号:黔科合支撑[2020]4Y161号),2020.12.30- 2023.12.30,贵州省科技厅,30万元。
(11)主持贵州省科学技术基金重点项目《RecQ解旋酶解链G4DNA结构调控去势抵抗性前列腺癌恶性转化的机制研究》(编号:黔科合基础ZK[2022]重点031),2021.01-2024.12,30万元。
(12)主持贵州省“百”层次创新型人才培养项目(编号黔科合平台人才-GCC[2022]034-1),2022.07-2027.07,贵州省省委组织部,100万元。
(13)主持贵州省科学技术基金项目《以Fli-1为靶标筛选抗白血病药物研究》(编号:黔科合J字[2014]2099号),2015.01-2017.12,贵州省科技厅,6万元。
(14)主持贵州省教育厅开发课题基金《一种新型普罗托品生物碱调节砷致肝损伤的分子机制研究,编号:黔教合KY字[2020]249》,2020-11-1-2022.10.30,5万元。
(15)主持与中国农业科学院烟草研究所合作横向项目《干旱胁迫条件下烤烟基因转录组及代谢组学分析》,2015.01-2015.12,中国农业科学院烟草研究所,12.75万元。
(17)主持与贵州万胜药业有限责任公司合作项目《廖氏化风丹在抗肿瘤应用方面的二次开发研究》,2016.10-2017.10,贵州万胜药业有限责任公司,5.5万元。
(18)主持与贵州万胜药业有限责任公司合作项目《苗药复方胃痛胶囊在抗肿瘤应用方面的二次开发研究》,2016.10-2017.10,贵州万胜药业有限责任公司,5.5万元。
(19)主持与贵州泰和现代生态农业科技有限公司合作项目《余庆小叶苦丁茶质量标准与保健品研发》,2020.10-2022.10.31,贵州泰和现代生态农业科技有限公司,35万元。
(21)主持与贵州万胜药业有限责任公司合作项目《复方胃痛胶囊作为抗肿瘤药物开发的成药性评价研究》,2021.05-2024.05,贵州万胜药业有限责任公司,25万元。
(23)主持贵州金蟾大山生物科技有限公司合作项目《红托竹荪菌盖菌托功能成分研究及其开发利用》,2021.12.01-2023.12.30,贵州金蟾大山生物科技有限公司,109.9万元。
Heng Luo, Hou-Qiang Xu*, Xiang Chen, Mei Ding, Qi-Xin Yang, Kun Li. Potent interference of DNA-binding, unwinding, and ATPase activities of Bloom helicase by fleroxacinin vitro. Biomedical and Environmental Sciences, 2013, 26(3):231-242
Heng Luo, Xiang Chen, Mei Ding, Qi-Xin Yang, Hou-Qiang Xu*. Study on The Mechanism of Effects of Lomefloxacin on Biological Properties of Bloom Syndrome Helicase[J]. Progress in biochemistry and biophysics, 2011, 34(11), 1060-1071.
Heng Luo, Hou-Qiang Xu*, Xiang Chen, Cao-Qian Liu, Qing-He Xu, Kun Li. Study on the interactions of Bloom helicase catalytic core with double-stranded DNA by fluorescence polarization technology [J]. Progress in biochemistry and biophysics,, 2013, 36(3), 245-256.
Heng Luo#, Yu-fen Xia#, Bao-fei Sun, Li-rong Huang, Xing-hui Wang, Hua-yong Lou, Xu-hui Zhu,Wei-dong Pan*, Xiao-dong Zhang*.Synthesis and Evaluation of In Vitro Antibacterial and Antitumor Activities of Novel N,N-Disubstituted Schiff Bases. BioMed Research International, 2017, 2017:1-10.
You-jun Li#,Heng Luo, Eldad Zacksenhaus and Yaacov Ben-David*. The ets transcription factor in development, cancer and diseases. Oncogene, 2016, 34:2022–2031.
Li-rong Huang#,Heng Luo#, Xiao-sheng Yang*, Lei Chen, Xiao-jiang Hao. Enhancement of anti-bacterial and -tumor activities of pentacyclic triterpenes by introducing exocyclic α, β-unsaturated ketone moiety in ring A. Medicinal Chemistry Research, 2014, 23:4631–4641.
Jianxin Hu#,Heng Luo#,Yuangao Xu, Guangheng Luo, Shuxiong Xu, Jianguo Zhu, Dalong Song, Zhaolin Sun & Youlin Kuang. The Prognostic Significance of EIF3C Gene during the Tumorigenesis of Prostate Cancer[J]. Cancer Investigation, 2019,37(4-5):199-208.
Lei Xia, Yu-Fen Xia, Li-Rong Huang, Xiao Xiao, Hua-yong Lou, Tang-Jingjun Liu, Wei-Dong Pan*,Heng Luo*. Benzaldehyde Schiff bases regulation to the metabolism, hemolysis, and virulence genes expression in vitro and their structure-microbicidal activity relationship [J]. European Journal of Medicinal Chemistry, 2015, 97 (2015) 83-93.
Li-Rong Huang, Xiao-Jiang Hao, Qi-Ji Li, Jian-Xin Zhang, Dao-Ping Wang,Heng Luo*, Xiao-Sheng Yang*. 18β-Glycyrrhetinic Acid Derivatives Possessing a Polyhydroxyl A-ring as Potent Gram-positive Bacteria Inhibitors. Journal of Natural Products, 2016, 79, 721−731.
Zheng-Ming Liang#, Xing-Hui Wang#, Li-Rong Huang, Qi-Ji Li, Tian-Qi Guan, Xiao-Jiang Hao,Heng Luo*, Xiao-Sheng Yang*. 1α, 2α-Epoxy -3b-hydroxy oleanolic acid derivatives regulation of the metabolism, haemolysis and b-lactamase gene expression in vitro and their structure–microbicidal activity relationship. Bioorganic & Medicinal Chemistry Letters, 2016, 26:3870–3875.
Chen Yan#, Yun-Dong Zhang#, Xing-Hui Wang, Shun-Dong Geng, Tian-Yuan Wang, Mao Sun, Wei Liang, Wei-Qing Zhang, Xiao-Dong Zhang*,Heng Luo*. Tirucallane-type triterpenoids from the fruits of Phellodendron chinense Schneid and their cytotoxic activities. Fitoterapia, 2016, 113(2):132-138.
Li-li Fang#, Bao-fei Sun#, Li-rong Huang, Hai-bo Yuan, Shuo Zhang, Jing Chen, Zi-jiang Yu* andHeng Luo*. Potent Inhibition of miR-34b on Migration and Invasion in Metastatic Prostate Cancer Cells by Regulating the TGF-β Pathway[J].Int. J. Mol. Sci. 2017, 18, 2762.
Li-li Fang#, Xing-hui Wang#, Bao-fei Sun, Xiao-dong Zhang, Xu-hui Zhu, Zi-jiang Yu* andHeng Luo*.Expression, regulation and mechanism of action of miR-17-92 cluster in tumor cells. International Journal of Molecular Medicine, 2017, 40: 1624-1630.
Zhong-hang Wen, Yong-qiang Zhang, Xing-hui Wang, Xiao-ping Zeng, Zhan-xing Hu,Yi Liu, Yu-xin Xie, Guang-yi Liang, Jian-guo Zhu*,Heng Luo*, Bi-xue Xu*.Novel 3’,5’-diprenylated chalcones inhibited the proliferation of cancer cells in vitro by inducing cell apoptosis and arresting cell cycle phase.European Journal of Medicinal Chemistry, 2017,133:227-239.
Yong-qiang Zhang, Zhong-hang Wen, Ke Wan, Dong-bo Yuan, Xiao-ping Zeng, Guang-yi Liang, Jian-guo Zhu⁎, Bi-xue Xu⁎,Heng Luo⁎. A novel synthesized 3’, 5’-diprenylated chalcone mediates the proliferation of human leukemia cells by regulating apoptosis and autophagy pathways[J]. Biomedicine & Pharmacotherapy, 106 (2018):794–804.
Lu Jin, Meng-Ling Wang, Yao Lv, Xue-Yi Zeng, Chao Chen, Hai Ren,Heng Luo*and Wei-Dong Pan*. Design and Synthesis of Flavonoidal Ethers and Their Anti-Cancer Activity In Vitro[J]. Molecules, 2019, 24, 1749-1759.
Sheng-You Li, Ze-Kun Sun, Xue-Yi Zeng, Yue Zhang, Meng-Ling Wang, Sheng-Cao Hu, Jun-Rong Song, Jun Luo, Chao Chen*,Heng Luo* and Wei-Dong Pan*. Potent Cytotoxicity of Novel L-Shaped Ortho-Quinone Analogs through Inducing Apoptosis[J]. Molecules, 2019, 24, 4138.
Youfen Ma, Bixue Xu, Jia Yu, Li-Rong Huang, Xiaoping Zeng, Xiangchun Sheng, Chunyan Ren, Yaacov Ben-David*,Heng Luo*. Fli-1 activation through targeted promoter activity regulation using a novel 3', 5'-diprenylated chalcone inhibits growth and metastasis of prostate cancer cells[J]. International Journal of Molecular Sciences, 2020,21, 2216
MengLing Wang#, Xueyi Zeng#, Shengyou Li, Zekun Sun, Jia Yu, Chao Chen, Xiangchun Shen, Weidong Pan*,Heng Luo*. A novel tanshinone analog exerts anti-cancer effects in prostate cancer by inducing cell apoptosis, arresting cell cycle at G2 phase and blocking metastatic ability [J].International Journal of Molecular Sciences, 2019, 20, 4459.
Yongqiang Zhang, Jue Yang, Zhonghang Wen, Jia Yu, Dongbo Yuan, Bixue Xu*,Heng Luo*, Jianguo Zhu*. A novel 3', 5'-diprenylated chalcone induces concurrent apoptosis and GSDME-dependent pyroptosis through activating PKCδ/JNK signal in prostate cancer[J]. Aging-US, 2020, 12(10): 9103.
Da-Wei Zhang #, Rong-Hua Luo#, Lei Xu, Liu-Meng Yang, Xiao-Shuang Xu, Yong-Tang Zheng*,Heng Luo*. Natural products library-based screening for discovery of capsid C-terminal domain 2 targeted HIV-1 inhibitor[J]. International Journal of Antimicrobial Agents, 2020,55 (2020) 105926.
Da-Wei Zhang #, Rong-Hua Luo#, Lei Xu, Liu-Meng Yang, Xiao-Shuang Xu,Heng Luo*. The selenium-containing drug ebselen potently disrupts LEDGF/p75-HIV-1 integrase interaction by targeting LEDGF/p75[J], Journal Of Enzyme Inhibition And Medicinal Chemistry, 2020, 35(1):906–912.
Jianxin Hu, Kehua Jiang, Xiaohu Tang, Hao Liu, Hu Zhang, Xuefeng Yang, Xiangqian Nie,Heng Luo*. Chronic exposure to di-n-butyl phthalate causes reproductive toxicity in zebrafish [J]. J Appl Toxicol. 2020, 1-10.
Xinying Mao#, Chunlin Wang #, Wuling Liu, Jia Yu, Zekun Sun, Mengling Wang,Heng Luo*. Anti-TMV Activity of Atisine-type Diterpene Alkaloids in Spiraea Japonica Associates with Down-Regulating the Expression of TMV Coat Protein[J]. Trends in Biochemical Engineering (2020) 1: 20-29.
Xu-hui Zhu#, Bao-fei Sun#, Mei Luo, Jia Yu, Yun-dong Zhang, Hou-qiang Xu*,Heng Luo*. Bloom helicase explicitly unwinds 3′-tailed G4DNA structure in prostate cancer cells [J], International Journal of Biological Macromolecules, 2021, 180 (2021) 578–589.
Jia Yu#, ShengyouLi#, Xueyi Zeng, Junrong Song, Shengcao Hu, Sha Cheng,Chao Chen*,Heng Luo*, Weidong Pan*.Design, synthesis, and evaluation of proliferation inhibitory activity of novel L-shaped ortho-quinone analogs as anticancer agents.Bioorganic Chemistry, 2021,117 (2021) 105383.
Li-rong Huang, Bing Wang, You-fen Ma, Mei Luo, Bao-fei Sun*,Heng Luo*.Prospective roles of IL-24 in the tumorgenesis and development of cancer [J]. Acta Poloniae Pharmaceutica-Drug Research, 2021,78(5):599–611.
Yufei Liu, Long Yang, Guijing Chen, Zhentao Liu, Tao Lu, Yong Yang, Jia Yu,Dongdong Kang, Wei Yan, Min He, Shuhao Qin, Jie Yu*, Chuan Ye*,Heng Luo*.PBAT hollow porous microfibers prepared via electrospinning and their functionalization for potential peptide release. Materials & Design 207 (2021) 109880.
Shuo Zhang, Jia Yu, Bao-fei Sun, Gui-zhong Hou, Zi-jiang Yu*,Heng Luo*. Inhibition of SERTAD3-dependent MicroRNA-92a alleviates Growth, invasive and migration of Prostate Cancer Cells via P53 pathway [J]. OncoTargets and Therapy, 2020, 13:5495–5514.
Jun-Feng Yang, Zhu Tao, Carl Redshaw, Xi Zeng*, HengLuo*.Color tuning and white light emission based on tetraphenylethylenefunctionalized cucurbit[7]uril and FRET triggered by host-guest selfassembly. Tetrahedron, 101 (2021) 132509.
Yuhe Chen,Jingsha Yang,Shuai Zhang,Xi Zeng*,Heng Luo*. Construction of a room-temperature phosphorescence system by cucurbit[8]uril-based supramolecular assembly. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2022,https://doi.org/10.1007/s10847-022-01129-2.
Bo Liu, Lei Hu, Jia Yu, Mei Luo, Qiong Wu, Xiaoping Zeng, Xia Wang, Lirong Huang*, Bixue Xu*,Heng Luo*.Simultaneous target-binding with TNFSF9, CYR61 and c-Jun by a novel L-phenylalanine dipeptide to inhibit prostate cancer cell proliferation. Journal of Cellular and Molecular Medicine, received, 2022.
Lanlan Li, Jia Yu, Sha Cheng, Zhilin Peng,Heng Luo*. Transcription factor Fli-1 as a new target for antitumor drug development. International Journal of Biological Macromolecules, 209 (2022) 1155–1168.
Xu-Hui Zhu, Long-Xi Han, Rong-Jie Zhang, Peng Zhang, Fu-Gang Chen,Jia Yu, Heng Luo*,Xiu-Wu Han*.The functional activity of donor kidneys is negativelyregulated by microribonucleic acid-451 in different perfusion methods to inhibit adenosinetriphosphate metabolism and the proliferation of HK2 cells.Bioengineered,2022,13:5, 12706-12717.
Bao-Fei Sun#, Xu-Hui Zhu#, Jing Hou, Lan-Lan Li, Yuan-Kun Qin, Jia Yu, Sha Cheng, Bi-Xue Xu*, Fa-Jun Song* andHeng Luo*Growth Inhibition of Two Prenylated Chalcones on Prostate Cancer Cells through the Regulation of the Biological Activity and Protein Translation of Bloom Helicase. Catalysts 2022, 12(6):582.
出版的专著:
[1]参编《中国毒性民族药志》(上、下卷),科学出版社,2015.
[2]作为副主编参与出版《土家族医药》,中医古籍出版社,2018.
[3]参编《贵州大健康产业特色发展读本》,贵州科技出版社,2019.
[4]主编《中国小叶苦丁茶》,科学出版社,2022.