杨元勇博士，教授，博士研究生导师

2007年毕业于四川大学获学士学位，2012年毕业于新加坡国立大学获博士学位，2012年到2014年在新加坡国立大学化学生物学从事研究工作，2014年下学期进入贵州医科大学药物化学教研室工作，药物化学教研室青年骨干教师。获得贵州省千层次创新型人才（2018），获贵州省自然科学三等奖第一获奖人（2020）。主持国家自然科学基金2项，主持省部级科研项目5项，在SCI收录的学术期刊上发表学术论文30余篇。主要从事有机不对称催化的方法学研究和鲍曼不动杆菌生物膜抑制剂的开发。不对称催化包括有机合成方法学开发，药物活性分子的路线设计，不对称催化合成和工艺开发等。细菌的生物膜是细菌耐药和院内感染的主要形式，对生物膜抑制剂的开发会极大程度上减轻细菌耐药和院内感染，基于此方法的小分子抑制剂有很好的发展前景。

联系方式：yangyuanyong@gmc.edu.cn

立项项目

1. 国家自然科学基金地区基金项目、22061012、空气参与的吲哚酮、喹啉酮和异喹啉酮的绿色反应研究、2021/01-2024/12、40万。

2. 国家自然科学基金、81660348、基于群体行为控制的鲍曼不动杆菌生物膜抑制剂的设计、合成及其构效关系研究、2017/1-2020/12、37万。

3. 贵州省科学技术厅、黔科合支撑[2020]4Y208、COVID-19潜在治疗药物氯喹与瑞德西韦的工艺路线优化、2021/01—2022/12、30万。

4. 贵阳市科技局基金、筑科合同[20151001] 药06号、基于群体行为控制的鲍曼不动杆菌生物膜抑制剂的设计、合成及其在医疗器械方面的应用、2016/1-2018/12、15万。

5. 贵州省科技厅贵州医科大学联合基金、黔科合LH字[2015]7343、鲍曼不动杆菌生物膜抑制剂的开发及其构效关系研究、2015/12- 2017/12、5万。

6. 贵州省教育厅重点领域项目、黔教合KY字[2021]047、基于鲍曼不动杆菌群体感应抑制剂的缓释抗菌涂层材料开发、2021-1-1至2023-12-31，20万。

7. 贵州医科大学博士启动基金、院博合J字[2014]015号、含三氟甲基手性二胺的合成、2014/6-2017/6、10万。

   发表文章

8. Xing-Lan Wang,Xue Bai,Chun-Feng Wu, Yong-Xi Dong, Min Zhang, Ling-Ling Fan, Lei Tang,*Yuan-Yong Yang,*Ji-Quan Zhang*, Direct C(sp3)-H Sulfonylation and Sulfuration Reactions ofIsoquinoline-1,3(2H,4H)-diones under Metal-free Conditions,Asian J. Org. Chem.2021,10, 386 –391.

9. Ying-Xian Li, Xiao-Bing Feng, Xue-Min Jia, Huang Jin, Fei Chen, Yong-Long Zhao,Ji-Quan Zhang, Jian-Ta Wang, Bing Guo, Lei Tang,* andYuan-Yong Yang*,Regiodivergent Functionalization of Isoquinoline-1,3(2H,4H)-dioneDerivatives via Aerobic Umpolung,Asian J. Org. Chem.2021,10,1508–1513.

10. Qing-Yan Zhang,Fei-Yu Yang,Shang-Gao Liao,Bing Wang,Rui Li,Yong-Xi Dong, Meng Zhou,Yuan-Yong Yang,*and Guo-Bo Xu,*Synthesis, Antibacterial Activity, and Structure–Activity Relationshipof Fusaric Acid AnalogsBull. Korean Chem. Soc.2021, 42, 577–582.

11. Cheng Cheng,Ying-Xian Li,Xue-Min Jia,Ji-Quan Zhang,Yong-Long Zhao,Wei Feng,Lei Tang*andYuan-Yong Yang*,Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives,RSC Adv.,2020,10, 42912(IF:3.119).

12. Ying-Xian Li, Cheng Cheng, Lei Tang andYuan-Yong Yang*,Palladium catalyzed asymmetric allylic alkylationof isoquinolinedione derivatives in the preparationof quaternary carbon stereocenters,Org. Biomol. Chem.,2020,18, 4551(IF:3.412)

13. Guo Yang,Cheng Cheng, Guo-Bo Xu, Lei Tang, Kim-Lee Chua*,Yuan-Yong Yang*,Synthesis and antibiofilm evaluation of 3-hydroxy-2,3-dihydroquinazolin-4(1H)-one derivatives against opportunistic pathogen Acinetobacterbaumannii,Bioorganic & Medicinal Chemistry,2020,28,115606(IF:3.073).

14. Cheng Cheng, Ying-Xian Li, Ji-Quan Zhang, Yong-Long Zhao, Lin Zhang,Chun Li, Yu-she Yang, Lei Tang,* andYuan-Yong Yang,*Organo-Catalyzed Asymmetric Amination of 4-Arylisoquinoline-1,3(2H,4H)-dione Derivatives in the Construction of QuaternaryStereocenters,Adv. Synth. Catal,2019,361, 5317– 5321(IF:5.851)

15. Yuanyong Yang, Yingxian Li, Zhenhua Zhang, Yonglong Zhao, and Wei Feng*,Metal-free N-formylation of 2-aminophenols usingdimethylformamide and CSA,Synthetic Communications,2019,49, 8, 1040–1046(IF:1.796)

16. Yuan-Yong Yang,*Guo Yang, Cheng Cheng, Ying-Xian Li, Ji-Quan Zhang, Wei Feng, 5 Yong-Long Zhao, and Lei Tang*,Catalyst-free Cleavage of Amide and C−O Double Bond for the 2 Diastereoselective Synthesis of Trifluoromethyl-Containing 3 Dihydrooxazole Derivatives,Organic. Letters.2019,21, 2236−2240(IF:6.091)

17. Yuanyong Yang*, Yingxian Li, Cheng Cheng, Guo Yang, Shuiying Wan, Jiquan Zhang, Yuanhu Mao,Yonglong Zhao, Lin Zhang, Chun Li, and Lei Tang*,Reductant-Free Aerobic Hydroxylation of Isoquinoline-1,3(2H,4H)‑dione Derivatives,The Journal of Organic Chemistry,2019,84, 2316-2324(IF:4.335)

18. Yuanyong Yang, Yingxian Li, Cheng Cheng, Guo Yang, Jiquan Zhang, Yi Zhang,Yonglong Zhao, Lin Zhang, Chun Li,* Lei Tang*Synthesis of 4‑Aryl Isoquinolinedione Derivatives by a Palladium-Catalyzed CouplingReaction of Aryl Halides with Isoquinoline-1,3(2H,4H)‑diones.J. Org. Chem.2018,83, 3348−3353.(IF:4.849)

19. Yong-Long Zhao*, Yong-Qin Tang, Xing-Hai Fei, Tao Xiao, Ya-Dong Lu, Xiao-Zhong Fu, Bin He, Meng Zhou, Chun Li, Peng-Fei Xu *,Yuan-Yong Yang*Palladium-catalyzed direct C(sp3)–H arylation ofindole-3-ones with aryl halides: a novel andefficient method for the synthesis of nucleophilic2-monoarylated indole-3-ones.RSC Advances,2018,8, 25292–25297.(IF:2.936)

20. Jun Cao,Zi-Li Chen, Shu-Min Li, Gao-Feng Zhu,Yuan-Yong Yang, Cong Wang, Wen-Zhang Chen, Jian-Ta Wang, Ji-Quan Zhang*, Lei Tang*. Palladium-catalyzed regioselective C-2 arylation of benzofurans with N'-acyl arylhydrazines.European Journal of Organic Chemistry,2018,2018(22),2774-2779.(IF:2.882)

21. Shun Zhou, Lin Zhang, Chun Li, Yuanhu Mao, Jianta Wang, Ping Zhao, Lei Tang*,Yuanyong Yang*Pentanidiumcatalyzed enantioselective hydroperoxidation of 2-oxindole using molecular oxygen. Catalysis Communication,2016,82, 29-31. (IF:3.389)

22. Jeng Yeong Chow,Yuanyong Yang, Song Buck Tay, Kim Lee Chua, Wen Shan Yew*Disruption of Biofilm Formation by the Human PathogenAcinetobacter baumannii Using Engineered Quorum-QuenchingLactonases.Antimicrobial Agents and Chemotherapy,2014, 58,1802–1805.(IF:4.302)

23. Yang Yuanyong, Chua Kim Lee. Assessment of efflux pump inhibitors on in vitro antimicrobial susceptibility of multidrug resistantAcinetobacter baumannii.Int. J. Antimicrob. Ag.2013,42, 283–284.(IF:4.259)

24. Richmond Lee#,Yuanyong Yang#, Geok Kheng Tan, Choon-Hong Tan, Kuo-Wei Huang. A novel heteroleptic paddlewheel diruthenium bicyclic guanidinate complex: synthesis, structure, and scope.Dalton Trans.,2010,39, 723 – 725.(IF:4.08)

25. Yuanyong Yang, Farhana Moinodeen, Chin Willy, Ting Ma, and Choon-Hong Tan. Pentanidium–Catalyzed Enantioselective α-Hydroxylation of Oxindoles Using Molecular Oxygen.Org. Lett.2012,14, 4762–4765.(IF:6.142)

26. Zhiyong Jiang,Yuanyong Yang, Yuanhang Pan, Yujun Zhao, Hongjun Liu, Choon-Hong Tan. Synthesis of alpha-Stereogenic Amides and Ketones via Enantioselective Conjugate Addition of 1,4-Dicarbonyl But-2-enes.Chem. Eur. J.2009,15, 4925 – 4930.(IF:5.454)

27. Zhiyong Jiang, Yuanhang Pan, Yujun Zhao, Ting Ma, Richmond Lee,Yuanyong Yang, Kuo-Wei Huang, Ming Wah Wong, Choon-Hong Tan. Synthesis of a Chiral Quaternary Carbon Center Bearing a Fluorine Atom: Enantio- and Diastereoselective Guanidine-Catalyzed Addition of Fluorocarbon Nucleophiles.Angew. Chem. Int. Ed.2009,121, 3681 – 3685.(IF:11.829)