杨元勇
2016-12-27 10:55   审核人:

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杨元勇PhD,副教授,硕士研究生导师

简历 2007年毕业于四川大学获学士学位,2012年毕业于新加坡国立大学获哲学博士学位,2012年到2014年在新加坡国立大学化学生物学从事博士后研究工作,2014年下学期进入贵州医科大学药物化学教研室工作。

研究领域及科研项目:主要从事有机不对称催化的方法学研究和饱满不动杆菌生物膜抑制剂的开发。不对称催化包括药物活性分子的路线设计,不对称合成和工艺开发等。细菌的生物膜是细菌耐药和院内感染的主要形式,对生物膜抑制剂的开发会极大程度上减轻细菌耐药和院内感染。基于此方法的抗菌材料有很好的发展前景。目前主持国家自然科学基金一项;主持贵州省科技厅贵州医科大学联合基金一项;主持贵阳市科技局基金一项;主持贵州科大学博士启动基金一项。在《Angewandte ChemieInternational Edition》,《Chemistry - A European Journal》《Organic Letters》等国际学术期刊发表过十余篇SCI研究论文。

发表论文:

1.       ShunZhou, Lin Zhang, Chun Li, Yuanhu Mao, Jianta Wang, Ping Zhao, Lei Tang*, YuanyongYang*. Pentanidiumcatalyzed enantioselective hydroperoxidation of2-oxindole using molecular oxygen. Catalysis Communications, 2016, 82, 29–31.

2.       YangYuanyong, Chua Kim Lee. Assessment of efflux pump inhibitors on invitro antimicrobial susceptibility of multidrug resistant Acinetobacterbaumannii. Int. J. Antimicrob. Ag. 2013, 42,283–284.

3.       YuanyongYang, Richmond Lee, Geok Kheng Tan, Choon-Hong Tan, Kuo-WeiHuang. A novel heteroleptic paddlewheel diruthenium bicyclic guanidinatecomplex: synthesis, structure, and scope. Dalton Trans., 2010, 39,723 – 725.

4.       YuanyongYang, Farhana Moinodeen, Chin Willy, Ting Ma, and Choon-HongTan. Pentanidium–Catalyzed Enantioselective α-Hydroxylation of Oxindoles UsingMolecular Oxygen. Org. Lett. 2012, 14, 4762–4765.

5.       ZhiyongJiang, Yuanyong Yang, Yuanhang Pan, Yujun Zhao, Hongjun Liu, Choon-HongTan. Synthesis of alpha-Stereogenic Amides and Ketones via EnantioselectiveConjugate Addition of 1,4-Dicarbonyl But-2-enes. Chem. Eur. J.2009,15, 4925 – 4930.

6.       JengYeong Chow, Yuanyong Yang, Song Buck Tay, Kim Lee Chua, Wen Shan Yew. Disruptionof Biofilm Formation by the Human Pathogen Acinetobacter baumannii UsingEngineered Quorum-Quenching Lactonases. Antimicrob. Agents Chemother.2014,58, 1802-1805.

7.       ZhiyongJiang, Weiping Ye, Yuanyong Yang, Choon-Hong Tan. Rate Acceleration ofTriethylamine-Mediated Guanidine- Catalyzed Enantioselective Michael Reaction.Adv. Synth. Catal. 2008, 350, 2345 – 2351.

8.       ZhiyongJiang, Yuanhang Pan, Yujun Zhao, Ting Ma, Richmond Lee, Yuanyong Yang,Kuo-Wei Huang, Ming Wah Wong, Choon-Hong Tan. Synthesis of a Chiral QuaternaryCarbon Center Bearing a Fluorine Atom: Enantio- and DiastereoselectiveGuanidine-Catalyzed Addition of Fluorocarbon Nucleophiles. Angew. Chem. Int.Ed. 2009, 121, 3681 – 3685.

9.       YuanhangPan, Yujun Zhao, Ting Ma, Yuanyong Yang, Hongjun Liu, Zhiyong Jiang,Choon-Hong Tan. Enantioselective Synthesis of alpha-Fluorinated beta-Amino AcidDerivatives by an Asymmetric Mannich Reaction and Selective Deacylation/DecarboxylationReactions. Chem. Eur. J. 2010, 16, 779 – 782.

10.    JianminWang, Hongjun Liu, Yitian Fan, Yuanyong Yang, Zhiyong Jiang, Choon-HongTan. Bicyclic Guanidine-Catalyzed Direct Asymmetric Allylic Addition of N-ArylAlkylidene-Succinimides. Chem. Eur. J. 2010, 16, 12534 –12537.

11.    YujunZhao, Yuanhang Pan, Hongjun Liu, Yuanyong Yang, Zhiyong Jiang,Choon-Hong Tan. Fluorinated Aromatic Ketones as Nucleophiles in the AsymmetricOrganocatalytic Formation of C–C and C–N Bonds: A Facile Route to the Constructionof Fluorinated Quaternary Stereogenic Centers. Chem. Eur. J. 2011,17, 3571 – 3574.

12.    YuanhangPan, Choon Wee Kee, Zhiyong Jiang, Ting Ma, Yujun Zhao, Yuanyong Yang,Hansong Xue, Choon-Hong Tan. Expanding the Utility of Brønsted Base Catalysis:Biomimetic Enantioselective Decarboxylative Reactions. Chem. Eur. J.2011,17, 8363 – 8370.

13.     YuanhangPan,Shuai Wang, Choon Wee Kee, Emilie Dubuisson, Yuanyong Yang, KianPing Loha, Choon-Hong Tan. Graphene oxide and Rose Bengal: oxidative C–Hfunctionalisation of tertiary amines using visible light. Green Chem., 2011,13, 3341–3344.

联系方式:yuanyong.yang@yahoo.com

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