令狐克刚，男，中共党员，副教授，贵州医科大学青年拔尖人才、青年硕士/博士生导师。澳门大学博士，澳门大学及贵州医科大学附属医院双博士后。目前是Journal of Pharmaceutical Analysis杂志青年编委，International Journal of Biological Macromolecules、Phytomedicine、International Immunopharmacology、Journal of Ethnopharmacology等多个国际期刊审稿人。
主讲课程
《药理学》；《中药药理学》
研究方向
炎症性及代谢性疾病的病理新机制研究；抗炎中药民族药及天然小分子药物的效应机制及分子靶标研究
联系方式
邮箱：Jacklinghu@126.com，yb77507@um.edu.mo
主持项目
1.国家自然科学基金青年基金(82404648),2025.1-2027.12
2.国家自然科学基金地区基金(8226080),2023.1-2026.12
3.中国博士后科学基金第73批面上项目(2023M730815),2023.7-2025.6
4.贵州省基础研究计划项目(黔科合基础-ZK[2024]152),2024.4-2027. 3
5.贵州医科大青年拔尖人才项目([2023]110号),2023.7-2028.6
6.贵州医科大学科技人才成长项目(22QNRC08),2023.1-2025.12
代表论文
1. Ke-Gang Linghu,et al.Small molecule α-methylene-γ-butyrolactone, anevolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB.Acta Pharmaceutica Sinica B, 2024,14 (8):3561-3575.
2. Tian Zhang#, Ke-Gang Linghu#,et al. TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes.Autophagy, 2024, 4,30:1-21.
3. Linghu KG, et al. Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy.Journal of Pharmaceutical Analysis,2024, 14(3): 401-415.
4. Linghu KG,et al.The "whole ingredients extract" of Astragali Radix improves the symptoms of dextran sulfate sodium-induced ulcerative colitis in mice through systemic immunomodulation.Chines Medicine, 2022, 17(1):109.
5. Zuo HL#, Linghu KG#,et al. Interactions of antithrombotic herbal medicines with Western cardiovascular drugs.Pharmacological Research, 2020:104963.
6.Linghu KG,et al. Leocarpinolide B attenuates LPS-induced inflammation on RAW264.7 macrophages by mediating NF-κB and Nrf2 pathways.European Journal of Pharmacology, 2020, 868:172854.
7. Linghu KG#,et al. Comprehensive comparison on the anti-inflammatory effects of three species of Sigesbeckia plants based on NF-κB and MAPKs signal pathways in vitro.Journal of Ethnopharmacology,2020, 250:112530.
8. Linghu KG#,et al. Siegesbeckia orientalis L. extract alleviated the collagen type Ⅱ -induced arthritis through inhibiting multi-targets-mediated synovial hyperplasia and inflammation.Frontiers in Pharmacology,2020, 11:547913.
