严雪龙，博士，副教授，青年博士生导师。
研究方向
生药学、天然药物化学
药食两用中药产品研发
联系方式：
电话 15250968467
电子邮件：yanxlong54@163.com
简介
主要研究方向为药用植物活性天然产物的挖掘、结构修饰、药效与作用机制、药食两用产品研发。2009-2016在中国药科大学中药学院本硕连读，分别获中药学学士及中药资源学硕士学位。2020年6月毕业于中山大学药学院，获生药学专业博士学位。2020年7月-2022年9月在贵州医科大学基础医学博士后科研流动站开展博士后研究，2020年9月出站后留校工作。迄今，在Journal of the American Chemical Society、Acta Pharmaceutica Sinica B、Journal of Medicinal Chemistry、Organic Letters、Bioorganic Chemistry等国际期刊上发表通讯及第一作者论文14篇。
经历
2020/10—至今 贵州医科大学药学院，副教授，青年博士生导师
2020/08—2022/09 贵州医科大学基础医学博士后科研流动站，博士后研究员
2016/09—2020/06 中山大学药学院，生药学、博士
2013/09—2016/07 中国药科大学，中药资源学，硕士
2009/09—2013/07 中国药科大学，中药学，学士
教学情况
1. 生药学
2. 中药鉴定学
3. 药用植物学
科研项目
1．国家自然科学基金，22167009：抗肥胖症瑞香烷型二萜小分子探针的构建及其靶点识别，35万元，主持，2022. 01-2025. 12。
2. 中国博士后科学基金，2021M693809：中药黄芫花中抗肥胖症瑞香烷型二萜的发现、结构修饰及构效关系研究，8万元，主持，已结题。
3. 贵州省科技厅基础研究计划重点项目，黔科合基础-ZK[2024]重点037：基于importin-b1为靶点抗去势抵抗性前列腺癌瑞香烷型二萜先导物的发现、构效关系及初步成药性研究，30万元，主持，2024.04~2028-04。
论著专利
(1) Xue-Long Yan, Yue-Hua Pan, Run-Zhu Fan, Qin-Qin Song, Shen Li, Jia-Luo Huang, Wei Li, Dong Huang, Fang-Yu Yuan, Gui-Hua Tang, Yong Rao,* Zhi-Shu Huang, and Sheng Yin*. Discovery of the First Raptor (Regulatory-Associated Protein of mTOR) Inhibitor as a New Type of Antiadipogenic Agent. Journal of Medicinal Chemistry, 2023, 66, 5839−5858. (中科院1区top, IF 8.039).
(2) Xue-Long Yan, Jun Sang, Shi-Xin Chen, Wei Li, Gui-Hua Tang, Li-She Gan, and Sheng Yin*. Euphorkanlide A, a Highly Modifified Ingenane Diterpenoid with a C24
Appendage from Euphorbia kansuensis. Organic Letters, 2019, 21, 4128−4131. (中科院1区top, IF 6.072)
(3) Jia-Luo Huang,# Xue-Long Yan,# Wei Li, Run-Zhu Fan, Shen Li, Jianghe Chen, Zhenhua Zhang, Jun Sang, Lu Gan, Gui-Hua Tang, Hongwu Chen, Junjian Wang,* and Sheng Yin*, Discovery of Highly Potent Daphnane Diterpenoids Uncovers Importin-β1 as a Druggable Vulnerability in Castration-Resistant Prostate Cancer. Journal of the American Chemical Society, 2022, 144, 17522−17532. (共同一作，中科院1区Top，IF 16.383)
(4) Jia-Luo Huang,# Xue-Long Yan,# Dong Huang, Lu Gan, Huahua Gao, Run-Zhu Fan, Shen Li, Fang-Yu Yuan, Xinying Zhu, Gui-Hua Tang, Hong-Wu Chen, Junjian Wang,* Sheng Yin*. Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer. Acta Pharmaceutica Sinica B, 2023, 13(12), 4934-4944. (共同一作，中科院1区Top，IF 14.5)
(5) Shen Li, Lu Gan, Yi-Jing Tian, Yang Tian, Run-Zhu Fan, Dong Huang, Fang-Yu Yuan, Xu Zhang, Yan Lin, Qin-Feng Zhu, Gui-Hua Tang, Xue-Long Yan,* Sheng Yin*. Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway. Bioorganic Chemistry, 2021, 114, 105222. (中科院1区，IF 5.307)
(6) Xue-Long Yan, Jun-Sheng Zhang, Jia-Luo Huang, Yao Zhang, Jia-Qi Chen, Gui-Hua Tang, Sheng Yin*. Euphonoids A−G, cytotoxic diterpenoids from Euphorbia fischeriana. Phytochemistry, 2019, 166, 112064. (中科院2区, IF 4.004).
(7) Xue-Long Yan, Bei-Ling Chen, Fang-Yu Yuan, Qin-Feng Zhu, Xu Zhang, Yan Lin, Qing-De Long, Shang-Gao Liao*. Six new tigliane diterpenoids with anti-inflammatory activity from Euphorbia kansuensis. Arabian Journal of Chemistry, 2022, 15, 103807. (中科院2区，IF 6.212)
(8) Xue-Long Yan, Ming-Feng Zou, Bei-Ling Chen, Fang-Yu Yuan, Qin-Feng Zhu, Xu Zhang, Yan Lin, Qing-De Long, Wu-Ling Liu*, Shang-Gao Liao*. Euphorane C, an unusual C17-norabietane diterpenoid from Euphorbia dracunculoides induces cell cycle arrest and apoptosis in human leukemia K562 cells. Arabian Journal of Chemistry, 2022, 15, 104203. (中科院2区，IF 6.212).
(9) Xue-Long Yan, Jun-Sang, Xu Zhang, Yan Lin, Qing-De Long, Qin-Feng Zhu, Shang-Gao Liao*. Euphorboside A, a cytotoxic meroterpenoid glycoside with an unusual humulene-phloroglucinol skeleton from Euphorbia kansuensis. Fitoterapia, 2021, 153, 104966. (中科院3区，IF 3.204).
(10) Bei-Ling Chen, Qin-Feng Zhu, Xu Zhang, Yan Lin, Qing-De Long, Wu-Ling Liu*, Xue-Long Yan*. An unusual indole-diterpenoid with C-17 norcassane skeleton from Euphorbia fischeriana induces HEL cell cycle arrest and apoptosis. Fitoterapia, 2022, 159, 105195. (中科院3区，IF 3.204).
